Okazaki M
Department of Dental Technology, Osaka University Faculty of Dentistry, Japan.
Biomaterials. 1991 Jan;12(1):46-9. doi: 10.1016/0142-9612(91)90131-s.
Fluoridated hydroxyapatites with various fluoride contents were synthesized with organic phosphate ester monomer as a source of P at pH 9.5 and 80 degrees C. The a-axis dimensions of the fluoridated hydroxyapatites decreased with the increase of the fluoride content in the same way as the fluoridated hydroxyapatites synthesized with inorganic phosphate under the same conditions. However, for the same calculated degree of fluoridation in the feed solution, fluoridated hydroxyapatites synthesized with organic P had higher fluoride contents than those synthesized with inorganic P. The crystallinity of the former decreased initially, then increased with increasing fluoride content; but on the whole it was lower than that of the latter. The apparent solubility at pH 4.0 and 37 degrees C decreased dramatically and monotonically with increasing fluoride content and approached an almost constant value at a fluoride content above that of fluorapatite, at which value calcium fluoride was detected.
以有机磷酸酯单体作为磷源，在pH值为9.5和80℃的条件下合成了具有不同氟含量的氟化羟基磷灰石。在相同条件下，与用无机磷酸盐合成的氟化羟基磷灰石一样，氟化羟基磷灰石的a轴尺寸随着氟含量的增加而减小。然而，对于进料溶液中相同的计算氟化度，用有机磷合成的氟化羟基磷灰石比用无机磷合成的具有更高的氟含量。前者的结晶度最初降低，然后随着氟含量的增加而增加；但总体上低于后者。在pH值为4.0和37℃时的表观溶解度随着氟含量的增加而急剧且单调下降，并且在氟含量高于氟磷灰石时接近一个几乎恒定的值，此时检测到了氟化钙。
