Department of Infectious Disease, Osaka Prefectural Institute of Public Health, Osaka City, Osaka, Japan.
Jpn J Infect Dis. 2010 Jan;63(1):65-6.
Chikungunya fever is an arboviral disease caused by chikungunya virus. A 37-year-old Japanese male visited India and developed fever, myalgia, rash, and persisting systemic arthralgia, the latter of which persisted for more than 2 months. The patient was diagnosed with chikungunya fever by virological and serological examinations. In the present study, we followed specific antibody responses over a 6-month period after the onset of the disease. IgM antibody was detected on days 58 and 108, but not on day 137, by enzyme-linked immunosorbent assay. Specific IgG and neutralizing antibodies were detected as late as day 192. The results indicate that specific IgM lasts for 3 to 4 months from the onset of the disease, and that IgG lasts more than 6 months.
基孔肯雅热是由基孔肯雅病毒引起的虫媒病毒性疾病。一名 37 岁的日本男性前往印度后出现发热、肌痛、皮疹和持续的全身性关节痛，后者持续了 2 个多月。通过病毒学和血清学检查，该患者被诊断为基孔肯雅热。本研究对发病后 6 个月内的特异性抗体反应进行了随访。酶联免疫吸附试验在第 58 天和第 108 天检测到 IgM 抗体，但在第 137 天未检测到。特异性 IgG 和中和抗体在第 192 天检测到。结果表明，从发病开始，特异性 IgM 持续 3 到 4 个月，而 IgG 持续 6 个月以上。
