Program in Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Nat Rev Cancer. 2010 Feb;10(2):102-15. doi: 10.1038/nrc2781.
The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy is associated with increases in genomic instability. Mitotic chromosomal instability - the inability to faithfully segregate equal chromosome complements to two daughter cells during mitosis - is a widespread phenomenon in solid tumours that is thought to serve as the fuel for tumorigenic progression. How chromosome instability (CIN) arises in tumours and what consequences it has are still, however, hotly debated issues. Here we review the recent literature with an emphasis on models that recapitulate observations from human disease.
从早期发育不良病变到全面转移恶性肿瘤的逐步进展与基因组不稳定性的增加有关。有丝分裂染色体不稳定性 - 在有丝分裂过程中无法忠实地将等量的染色体组分配到两个子细胞中 - 是实体瘤中普遍存在的现象，被认为是肿瘤发生进展的燃料。然而，染色体不稳定性（CIN）在肿瘤中是如何产生的，以及它有什么后果，仍然是激烈争论的问题。在这里，我们重点回顾了最近的文献，这些文献强调了能够再现人类疾病观察结果的模型。
