血管生态位通过血管生成因子在促进肿瘤生长和组织修复中的指导作用。
Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors.
机构信息
Hideki Kobayashi and Shahin Rafii are at the Howard Hughes Medical Institute, Ansary Stem Cell Institute, Department of Genetic Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
出版信息
Nat Rev Cancer. 2010 Feb;10(2):138-46. doi: 10.1038/nrc2791.
Abstract
The precise mechanisms whereby anti-angiogenesis therapy blocks tumour growth or causes vascular toxicity are unknown. We propose that endothelial cells establish a vascular niche that promotes tumour growth and tissue repair not only by delivering nutrients and O2 but also through an 'angiocrine' mechanism by producing stem and progenitor cell-active trophogens. Identification of endothelial-derived instructive angiocrine factors will allow direct tumour targeting, while diminishing the unwanted side effects associated with the use of anti-angiogenic agents.
摘要
抗血管生成治疗阻断肿瘤生长或引起血管毒性的确切机制尚不清楚。我们提出，内皮细胞通过不仅提供营养和 O2，而且通过产生干细胞和祖细胞活性营养因子的“血管分泌”机制，建立促进肿瘤生长和组织修复的血管小生境。鉴定内皮细胞衍生的有指导作用的血管分泌因子将允许直接靶向肿瘤，同时减少与使用抗血管生成剂相关的不必要的副作用。
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