Bikfalvi Andreas, Bicknell Roy
INSERM E 0113 Molecular Mechanisms of Angiogenesis and Growth Factor and Cell Differentiation Laboratory, University Bordeaux I, France.
Trends Pharmacol Sci. 2002 Dec;23(12):576-82. doi: 10.1016/s0165-6147(02)02109-0.
Angiogenesis, the development of new blood vessels, has become a major focus of research. This has been stimulated by the therapeutic opportunities offered by the ability to manipulate the vasculature in pathologies such as cancer. Here, we present an overview of recent advances in angiogenesis. Especially noteworthy is the large volume of information from developmental studies, particularly those that involve transgenic and gene knockout mice. We also discuss the increasing repertoire of drugs with which to manipulate angiogenesis and new endothelial-specific genes with which to target the vasculature.
血管生成，即新血管的形成，已成为研究的主要焦点。这是受到了在癌症等病理学中操控脉管系统所带来的治疗机遇的刺激。在此，我们概述血管生成方面的最新进展。特别值得注意的是来自发育研究的大量信息，尤其是那些涉及转基因和基因敲除小鼠的研究。我们还讨论了用于操控血管生成的药物种类不断增加，以及用于靶向脉管系统的新的内皮细胞特异性基因。
