Zhang Lijuan, Falla Timothy J
Helix Biomedix Inc., Bothell, WA, USA.
Methods Mol Biol. 2010;618:303-27. doi: 10.1007/978-1-60761-594-1_19.
Host defense peptides (HDPs) are relatively small, mostly cationic, amphipathic, and of variable length, sequence, and structure. The majority of these peptides exhibit broad-spectrum antimicrobial activity and often activity against viruses and some cancer cell lines. In addition, HDPs also provide a range of immunomodulatory activities related to innate immunity defense, inflammation, and wound healing. The development of these multi-faceted molecules and their bioactivities into clinically important therapeutics is being pursued using a number of different approaches. Here we review the role of HDPs in nature and application of this role to the development of novel therapeutics.
宿主防御肽（HDPs）相对较小，大多呈阳离子性、两亲性，长度、序列和结构各异。这些肽中的大多数具有广谱抗菌活性，并且常常对病毒和一些癌细胞系具有活性。此外，宿主防御肽还具有一系列与固有免疫防御、炎症和伤口愈合相关的免疫调节活性。目前正在采用多种不同方法将这些具有多方面作用的分子及其生物活性开发成具有临床重要性的治疗药物。在此，我们综述宿主防御肽在自然界中的作用以及将该作用应用于新型治疗药物开发的情况。
