Center for Microbial Diseases Research, University of British Columbia, Vancouver, British Columbia, V6H 3Z6, Canada.
Nat Rev Immunol. 2016 May;16(5):321-34. doi: 10.1038/nri.2016.29. Epub 2016 Apr 18.
Host defence peptides (HDPs) are short, cationic amphipathic peptides with diverse sequences that are produced by various cells and tissues in all complex life forms. HDPs have important roles in the body's response to infection and inflammation. This Review focuses on human HDPs and explores the diverse immunomodulatory effects of HDPs from a systems biology perspective, which highlights the interconnected nature of the effect (or effects) of HDPs on the host. Studies have demonstrated that HDPs are expressed throughout the body and mediate a broad range of activities, which explains their association with various inflammatory diseases and autoimmune disorders. The diverse actions of HDPs, such as their roles in wound healing and in the maintenance of the microbiota, are also explored, in addition to potential therapeutic applications.
宿主防御肽（HDPs）是一类短的、阳离子性、两亲性肽，具有多样化的序列，由所有复杂生命形式中的各种细胞和组织产生。HDPs 在机体对感染和炎症的反应中具有重要作用。本综述聚焦于人类 HDPs，并从系统生物学的角度探讨了 HDPs 的多种免疫调节作用，突出了 HDPs 对宿主影响的相互关联性质。研究表明，HDPs 在全身表达，并介导广泛的活性，这解释了它们与各种炎症性疾病和自身免疫性疾病的关联。除了潜在的治疗应用外，还探讨了 HDPs 的多种作用，如其在伤口愈合和维持微生物群中的作用。
