Laboratory for Molecular Oncology and Wound Healing, Department of Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr-University Bochum, Buerkle-de-la Camp-Platz-1, 44789 Bochum, Germany.
Immunobiology. 2011 Mar;216(3):322-33. doi: 10.1016/j.imbio.2010.07.003. Epub 2010 Aug 19.
Host defence peptides (HDPs) are short cationic molecules produced by the immune systems of most multicellular organisms and play a central role as effector molecules of innate immunity. Host defence peptides have a wide range of biological activities from direct killing of invading pathogens to modulation of immunity and other biological responses of the host. HDPs have important functions in multiple, clinically relevant disease processes and their imbalanced expression is associated with pathology in different organ systems and cell types. Furthermore, HDPs are now evaluated as model molecules for the development of novel natural antibiotics and immunoregulatory compounds. This review provides an overview of HDPs focused on their antimicrobial-immunomodulatory duality.
宿主防御肽 (HDPs) 是大多数多细胞生物免疫系统产生的短阳离子分子，作为先天免疫的效应分子发挥着核心作用。宿主防御肽具有广泛的生物学活性，从直接杀死入侵病原体到调节宿主的免疫和其他生物反应。HDPs 在多种临床相关疾病过程中具有重要功能，其表达失衡与不同器官系统和细胞类型的病理学有关。此外，HDPs 现在被评估为开发新型天然抗生素和免疫调节化合物的模型分子。本综述重点介绍 HDPs 的抗菌-免疫调节双重性。
