衍生染色体9短臂在费城染色体阳性急性淋巴细胞白血病中的累及情况。
Involvement of the short arm of the derivative chromosome 9 in Philadelphia-positive acute lymphoblastic leukemia.
作者信息
Sessarego M, Defferrari R, Fugazza G, Comelli A, Salvidio E, Ajmar F
机构信息
Cattedrà di Clinica Medica II, Università di Genova, Italy.
出版信息
Cancer Genet Cytogenet. 1991 Mar;52(1):43-9. doi: 10.1016/0165-4608(91)90052-v.
Three Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) patients showed rearrangement of the short arm of the chromosome 9 involved in Ph formation. At diagnosis, blast cells were morphologically L2 and phenotypically B-cell precursors, as shown by common ALL antigen (CALLA), B1, B4 and HLA-DR positivity. Cytogenetically, they had in common the presence of cells with normal karyotypes, the Ph, involvement of band 9p13----p21, and loss of region 9p13----9pter. In our experience, involvement of the p arm of the derivative chromosome 9 in Ph+ leukemias is a very rare event found in ALLs only.
三名费城染色体（Ph）阳性急性淋巴细胞白血病（ALL）患者显示出与Ph形成相关的9号染色体短臂重排。诊断时，原始细胞在形态上为L2型，表型上为B细胞前体，表现为常见ALL抗原（CALLA）、B1、B4和HLA-DR阳性。细胞遗传学上，它们的共同特征是存在核型正常的细胞、Ph染色体、9p13----p21带受累以及9p13----9pter区域缺失。根据我们的经验，衍生9号染色体的p臂在Ph+白血病中的受累是一种仅在ALL中发现的非常罕见的情况。
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