Zollino M, Leone G, Sica S, Bajer J, Neri G
Istituto di Genetica Medica, Facoltà di Medicina e Chirurgia A. Gemelli, Università Cattolica, Rome, Italy.
Cancer Genet Cytogenet. 1993 Feb;65(2):115-9. doi: 10.1016/0165-4608(93)90218-b.
We report three cases of trisomy 4 in acute leukemia. This alteration was detected as the sole cytogenetic abnormality in a case of FAB M4 leukemia; it occurred in association with 5q deletion in a case of M1, and concomitant with Ph chromosome and trisomy 17 in a case of L2 leukemia. The latter case represents the fourth report of trisomy 4 in acute lymphoblastic leukemia.
我们报告了3例急性白血病中4号染色体三体的病例。在1例FAB M4白血病病例中，该改变被检测为唯一的细胞遗传学异常；在1例M1病例中，它与5号染色体长臂缺失同时出现；在1例L2白血病病例中，它与费城染色体及17号染色体三体同时存在。后1例病例是急性淋巴细胞白血病中4号染色体三体的第四例报告。
