Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China.
Langmuir. 2010 May 18;26(10):7523-8. doi: 10.1021/la904329q.
Poly(dG)-poly(dC) DNA and G4-DNA are two types of synthetic molecules that are regarded as promising candidates for molecular nanodevices. In this work, vibrating scanning polarization force microscopy (VSPFM) was employed to study the radial deformability of these two molecules coadsorbed on a Ni(2+)-modified mica surface. The values of the radial compressive elastic modulus of these two types of molecules were found to be similar (approximately 5-10 MPa) when the external loading force was between approximately 0.04 and approximately 0.12 nN. However, G4-DNA molecules possessed higher stiffness than poly(dG)-poly(dC) DNA (approximately 20-40 vs approximately 10-20 MPa) when the loading force was larger than approximately 0.12 nN. The results will aid us in understanding these molecule's mechanical performances.
聚（dG）-聚（dC）DNA 和 G4-DNA 是两种被认为有前途的分子纳米器件候选合成分子。在这项工作中，振动扫描极化力显微镜（VSPFM）被用于研究这两种共吸附在 Ni（2+）修饰云母表面上的分子的径向可变形性。当外部加载力在大约 0.04 到大约 0.12 nN 之间时，发现这两种分子的径向压缩弹性模量值相似（大约 5-10 MPa）。然而，当加载力大于大约 0.12 nN 时，G4-DNA 分子比聚（dG）-聚（dC）DNA 具有更高的刚性（大约 20-40 对大约 10-20 MPa）。这些结果将有助于我们理解这些分子的机械性能。
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