（R）-和（S）-5-羟基-2-氨基茚满-2-羧酸的构象约束酪氨酸类似物的合成。

Synthesis of the conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids.

机构信息

Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721-0041, USA.

出版信息

J Org Chem. 2010 Feb 19;75(4):1293-6. doi: 10.1021/jo902438s.

PMID:20095557

Abstract

The conformationally constrained tyrosine analogues, (R)- and (S)-5-hydroxy-2-aminoindan-2-carboxylic acids, were prepared by chromatographic separation of diastereomeric dipeptide derivatives formed from N-Boc-L-phenylalanine. Absolute configurations were assigned by X-ray crystallographic analysis.

摘要

（R）-和（S）-5-羟基-2-氨基茚满-2-羧酸这两种构象受限的酪氨酸类似物是通过对 N-Boc-L-苯丙氨酸形成的非对映二肽衍生物进行色谱分离制备的。通过 X 射线晶体学分析确定了绝对构型。