从酮类化合物到氟化缩水甘油酯的首次高效合成。

First efficient synthesis of fluorinated glycidic esters from ketones.

机构信息

INSA de Rouen et Université de Rouen, CNRS UMR 6014 COBRA & FR 3038, IRCOF, Mont-Saint-Aignan Cedex, France.

出版信息

Org Lett. 2010 Feb 19;12(4):844-6. doi: 10.1021/ol902903v.

PMID:20095572

Abstract

Treatment of various ketones with ethyl dibromofluoroacetate in the presence of diethylzinc and dimethylaminoethanol or triphenylphosphine provides rapid access to corresponding fluorinated glycidic esters. Simplified workup allowed first characterization of these compounds.

摘要

各种酮与乙基二溴氟代乙酸酯在二乙基锌和二甲氨基乙醇或三苯基膦的存在下反应，可快速得到相应的氟化缩水甘油酯。简化的后处理方法允许对这些化合物进行初步表征。