Laboratory of Mesoscopic Chemistry and Department of Polymer Science & Engineering, College of Chemistry & Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
Langmuir. 2010 Apr 20;26(8):5428-34. doi: 10.1021/la903893n.
Multifunctional nanocarriers based on chitosan/gold nanorod (CS-AuNR) hybrid nanospheres have been successfully fabricated by a simple nonsolvent-aided counterion complexation method. Anticancer drug cisplatin was subsequently loaded into the obtained hybrid nanospheres, utilizing the loading space provided by the chitosan spherical matrix. In vitro cell experiments demonstrated that the CS-AuNR hybrid nanospheres can not only be utilized as contrast agents for real-time cell imaging but also serve as a near-infrared (NIR) thermotherapy nanodevice to achieve irradiation-induced cancer cell death owing to the unique optical properties endowed by the encapsulated gold nanorods. In addition, an effective attack on the cancer cells by the loaded anticancer drug cisplatin has also been observed, rendering the obtained nanocarriers an all-in-one system possessing drug delivery, cell imaging, and photothermal therapy functionalities.
基于壳聚糖/金纳米棒（CS-AuNR）杂化纳米球的多功能纳米载体已通过简单的非溶剂辅助抗衡离子络合法成功制备。随后，利用壳聚糖球形基质提供的装载空间，将抗癌药物顺铂载入所得杂化纳米球中。体外细胞实验表明，CS-AuNR 杂化纳米球不仅可用作实时细胞成像的造影剂，还可用作近红外（NIR）热疗纳米器件，由于封装的金纳米棒赋予的独特光学性质，实现了辐照诱导的癌细胞死亡。此外，还观察到负载的抗癌药物顺铂对癌细胞的有效攻击，使所得纳米载体成为具有药物输送、细胞成像和光热治疗功能的一体化系统。
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