Departamento de Física, Universidad Autónoma Metropolitana-Iztapalapa, 09340 Mexico, D.F., Mexico.
J Chem Phys. 2010 Jan 21;132(3):035103. doi: 10.1063/1.3293098.
We propose a model for protein folding in vivo based on a Brownian ratchet mechanism in the multidimensional energy landscape space. The device is able to produce directed transport taking advantage of the assumed intrinsic asymmetric properties of the proteins and employing the consumption of energy provided by an external source. Through such a directed transport phenomenon, the polypeptide finds the native state starting from any initial state in the energy landscape with great efficacy and robustness, even in the presence of different types of obstacles. This model solves Levinthal's paradox without requiring biased transition probabilities but at the expense of opening the system to an external field.
我们提出了一个基于多维能量景观空间布朗棘轮机制的体内蛋白质折叠模型。该设备能够利用蛋白质的内在不对称特性和外部能源的消耗来产生定向输运。通过这种定向输运现象，多肽能够从能量景观中的任何初始状态出发，高效且稳健地找到天然状态，即使存在不同类型的障碍也是如此。该模型解决了莱文塔尔悖论，而无需偏向跃迁概率，但代价是将系统暴露于外部场中。
