Department of Public Health, Tzu Chi University, Taiwan.
Radiat Res. 2010 Feb;173(2):197-204. doi: 10.1667/RR1850.1.
The objective of this study was to assess lenticular changes in a young population years after exposure to protracted long-term low-dose-rate gamma radiation in Taiwan. A total of 41 males and 32 females who lived for several years in (60)Co-contaminated buildings and were less than 20 years old at their first ophthalmological examination in 1998 had a similar examination 4.7 +/- 0.5 years later. Lens opacities were examined by slit-lamp biomicroscopy and were scored by the Lens Opacities Classification System III (LOCS III) and a modified subclinical minor focal lens defect (FLD) system. The FLD scores for both eyes were significantly higher than those in the 1998 examinations. Increases in FLD scores compared to those for unexposed subjects occurred particularly in the anterior lens cortex. Increases in FLD scores were also significantly associated with the amount of previous protracted radiation exposure. An exposure-dependent increase in lens opacities was noted years after individuals relocated from the radiocontaminated environment, suggesting that late lenticular changes persisted and progressed in individuals with previous protracted radiation exposure.
本研究旨在评估台湾地区长期低剂量率γ辐射暴露后数年年轻人群晶状体的变化。共有 41 名男性和 32 名女性在 1998 年首次眼科检查时居住在（60）Co 污染的建筑物中，且年龄均小于 20 岁，他们在 4.7 +/- 0.5 年后接受了类似的检查。晶状体混浊通过裂隙灯生物显微镜检查，并通过晶状体混浊分类系统 III（LOCS III）和改良的亚临床小焦点晶状体缺陷（FLD）系统进行评分。双眼的 FLD 评分均明显高于 1998 年的检查结果。与未暴露组相比，前晶状体皮质的 FLD 评分增加尤其明显。与未暴露组相比，FLD 评分的增加与之前的迁延性辐射暴露量显著相关。从放射性污染环境中搬迁数年后，仍观察到晶状体混浊的剂量依赖性增加，表明迁延性辐射暴露后晶状体的迟发性改变持续存在并进展。
