Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
J Womens Health (Larchmt). 2010 Feb;19(2):245-50. doi: 10.1089/jwh.2009.1396.
To investigate the association between the presence and characteristics of uterine leiomyomata (UL) and self-reported stress urinary incontinence (SUI).
The study included 836 premenopausal participants (474 African American and 362 Caucasian) in the National Institute of Environmental Health Sciences (NIEHS) Uterine Fibroid Study. UL were characterized at baseline with ultrasound screening, and SUI was assessed at follow-up (after 4 years, on average). Linear risk models were used to estimate adjusted prevalence differences (aPD) and 95% confidence intervals (CI), controlling for age, ethnicity, body mass index (BMI), and number of deliveries.
Compared with women without UL, SUI prevalence was higher among women with any UL (aPD = 7.4%, 95% CI 0.4-14.3) and women with UL 2-4 cm (aPD = 9.6%, 95% CI 1.3-17.9). Marginally significant results were found for the presence of UL > or =4 cm and anterior UL > or =2 cm.
The observed 7% increase in prevalence of this common condition for women with UL is of clinical importance. Further research is needed before concluding that treatment for larger UL might enhance SUI treatment in some women.
探讨子宫平滑肌瘤（UL）的存在和特征与自我报告的压力性尿失禁（SUI）之间的关联。
该研究纳入了国家环境卫生科学研究所（NIEHS）子宫纤维瘤研究中的 836 名绝经前参与者（474 名非裔美国人和 362 名白种人）。UL 采用超声筛查在基线时进行特征描述，SUI 在随访时（平均随访 4 年后）进行评估。采用线性风险模型来估计调整后的患病率差异（aPD）和 95%置信区间（CI），同时控制年龄、种族、体重指数（BMI）和分娩次数。
与没有 UL 的女性相比，任何 UL（aPD = 7.4%，95%CI 0.4-14.3）和 2-4cm UL（aPD = 9.6%，95%CI 1.3-17.9）的女性中 SUI 的患病率更高。UL >或=4cm 和前 UL >或=2cm 的结果也存在边际显著。
对于患有 UL 的女性，观察到的这种常见疾病患病率增加 7%，具有临床重要性。在得出治疗更大 UL 可能会增强某些女性 SUI 治疗效果的结论之前，还需要进一步研究。
