Ekin Murat, Cengiz Huseyin, Öztürk Emine, Kaya Cihan, Yasar Levent, Savan Kadir
Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Tevfik Sağlam Street, No: 11, Zuhuratbaba, Bakirkoy, Istanbul, Turkey.
Int Urogynecol J. 2014 Jun;25(6):807-10. doi: 10.1007/s00192-013-2295-4. Epub 2014 Jan 17.
This study was designed to determine the presence of genitourinary symptoms and their effects on quality of life (QOL) in women with uterine myomas.
A total of 145 women with ultrasonography (US) diagnosis of anterior myoma were divided into two groups according to myoma size: (1) those ≤5 cm (n = 75), and (2) those >5 cm (n = 70). The control group comprised previously matched 94 women with a normal-appearing uterus on US. Study participants answered the Urogenital Distress Inventory (UDI-6) and the Incontinence Impact Questionnaire (IIQ-7). Pelvic examination was performed, and urinary symptoms were recorded. The chi-square test and Fischer's exact test were used to compare qualitative data. The Kruskal-Wallis test and Dunn's test were used to compare groups. Statistical significance was set at P <0.05.
The frequency of genitourinary symptoms was significantly higher in women with myomas, including stress urinary incontinence (SUI), urgency, frequency, urge urinary incontinence (UUI), and dyspareunia. SUI and mixed urinary incontinence (MUI) were the most common symptoms associated with myoma size. Total UDI-6 scores were significantly higher in women with myomas than in control patients (P < 0.0001). UDI scores associated with UI and obstructive symptoms were higher in women with myomas >5 cm than in other women. IIQ scores regarding physical activity, travel, and emotional health were significantly higher in women with myomas >5 cm than in other women (P < 0.001).
Urinary tract dysfunction is associated with anterior myomas, increasing in association with myoma size, and significantly affects QOL.
本研究旨在确定子宫肌瘤女性患者泌尿生殖系统症状的存在情况及其对生活质量（QOL）的影响。
共有145名经超声（US）诊断为前壁肌瘤的女性，根据肌瘤大小分为两组：（1）肌瘤≤5 cm者（n = 75），（2）肌瘤>5 cm者（n = 70）。对照组由94名US检查显示子宫外观正常且年龄匹配的女性组成。研究参与者回答了泌尿生殖系统困扰量表（UDI - 6）和尿失禁影响问卷（IIQ - 7）。进行了盆腔检查，并记录了泌尿系统症状。采用卡方检验和费舍尔精确检验比较定性数据。采用Kruskal - Wallis检验和邓恩检验比较各组数据。设定统计学显著性水平为P <0.05。
肌瘤女性患者泌尿生殖系统症状的发生率显著更高，包括压力性尿失禁（SUI）、尿急、尿频、急迫性尿失禁（UUI）和性交困难。SUI和混合性尿失禁（MUI）是与肌瘤大小相关的最常见症状。肌瘤女性患者的UDI - 6总分显著高于对照组患者（P <0.0001）。肌瘤>5 cm的女性患者中，与尿失禁和梗阻性症状相关的UDI评分高于其他女性。肌瘤>5 cm的女性患者在身体活动、旅行和情绪健康方面的IIQ评分显著高于其他女性（P <0.001）。
尿路功能障碍与前壁肌瘤相关，随肌瘤大小增加而加重，并显著影响生活质量。
