Department of Otolaryngology-Head & Neck Surgery, Lahey Clinic, Burlington, MA, USA.
Otolaryngol Head Neck Surg. 2010 Jan;142(1):129-31. doi: 10.1016/j.otohns.2009.10.010.
Inflammatory pseudotumor is an idiopathic, non-neoplastic mass lesion with few cases reported in the literature involving only the skull base and related structures. Imaging of skull-base pseudotumors shows characteristics similar to that of nasopharyngeal carcinoma and lymphoma, thereby requiring a biopsy to exclude malignancy. Surgical versus medical management relates to the location of the mass, the extent of bony invasion, and the involvement of corresponding anatomic structures.
A retrospective chart review of patients diagnosed with inflammatory pseudotumor of the skull base from a single tertiary care institution over a five-year period.
Five cases of skull-base pseudotumor have been identified and followed from one to four years. In our clinical experience, maintenance oral corticosteroids have proven effective in improving symptoms and significantly reducing radiologic tumor dimensions.
Inflammatory pseudotumor of the skull base is a challenging diagnosis due to its occult anatomic location, vague associated symptoms, and nonspecific histology. Low-dose oral corticosteroids are often very effective in management.
炎性假瘤是一种特发性、非肿瘤性的肿块病变，文献中仅有少数病例仅涉及颅底及相关结构。颅底假性肿瘤的影像学表现与鼻咽癌和淋巴瘤相似，因此需要进行活检以排除恶性肿瘤。手术与药物治疗的选择取决于肿块的位置、骨侵犯的程度以及相应解剖结构的受累情况。
对一家三级医疗机构在五年期间诊断为颅底炎性假瘤的患者进行回顾性图表审查。
已确定并随访了 5 例颅底假性肿瘤，随访时间为 1 至 4 年。在我们的临床经验中，维持口服皮质类固醇已被证明可有效改善症状并显著缩小肿瘤的影像学尺寸。
由于其隐匿的解剖位置、模糊的相关症状和非特异性组织学，颅底炎性假瘤的诊断具有挑战性。低剂量口服皮质类固醇通常在治疗中非常有效。
