Department of Chemistry, Himachal Pradesh University, Shimla 171005, Himachal Pradesh, India.
Int J Pharm. 2010 Apr 15;389(1-2):94-106. doi: 10.1016/j.ijpharm.2010.01.022. Epub 2010 Jan 21.
In order to exploit the potential of gel forming medicinally important polysaccharide, we have developed psyllium based hydrogels through graft copolymerization. The optimum conditions for the synthesis of psyllium-poly(vinyl alcohol) (PVA)-poly(acrylic acid) blended hydrogels have been evaluated and their characterization has been carried out by SEMs, FTIR and swelling studies. The optimum conditions for the synthesis of hydrogels have been obtained as 1% (v/v) acrylic acid, 2% (w/v) PVA and 1g of psyllium. The use of very small amount of these petroleum products has developed the low energy, cost effective, biodegradable and biocompatible material for potential biomedical applications. It is the novelty of the present finding. The release of model antibiotic drug tetracycline HCl from the hydrogels has been observed more in pH 2.2 buffer hence these hydrogels are suitable for peptic ulcer caused by Helicobacter pylori. At the same time psyllium has also been reported to cure the ulcerative colitis. Hence, the present drug delivery system will have double potential to cure ulcer. The values of the diffusion exponent for the release of drug have been obtained as (0.774, 0.576 and 0.858) and gel characteristic constant have been (8.884x10(-3), 24.149x10(-3) and 3.989x10(-3)) respectively in pH 2.2 buffer, 7.4 buffer and distilled water. The release of the drug from the hydrogels occurred through non-Fickian diffusion mechanism.
为了开发具有医学重要性的凝胶形成多糖的潜力，我们通过接枝共聚开发了基于车前草的水凝胶。通过 SEM、FTIR 和溶胀研究评估了合成车前草-聚乙烯醇（PVA）-聚丙烯酸共混水凝胶的最佳条件，并对其进行了表征。水凝胶合成的最佳条件为 1%（v/v）丙烯酸、2%（w/v）PVA 和 1g 车前草。使用非常少量的这些石油产品开发了低能耗、具有成本效益、可生物降解和生物相容的材料，可用于潜在的生物医学应用。这是目前发现的新颖之处。观察到模型抗生素药物盐酸四环素 HCl 从水凝胶中在 pH 2.2 缓冲液中释放更多，因此这些水凝胶适用于由幽门螺杆菌引起的消化性溃疡。同时，车前草也被报道可以治疗溃疡性结肠炎。因此，目前的药物输送系统将具有双重潜力来治愈溃疡。在 pH 2.2 缓冲液、7.4 缓冲液和蒸馏水中，药物释放的扩散指数值分别为（0.774、0.576 和 0.858），凝胶特征常数分别为（8.884x10(-3)、24.149x10(-3) 和 3.989x10(-3)）。药物从水凝胶中的释放通过非 Fickian 扩散机制发生。
