Department of Chemistry, Himachal Pradesh University, Shimla, India.
J Mater Sci Mater Med. 2012 Apr;23(4):1021-32. doi: 10.1007/s10856-012-4582-x. Epub 2012 Feb 25.
The present article discusses the synthesis, characterization and haemocompatibility behaviour of the psyllium-PVA hydrogels prepared by chemical method in the presence of N,N'-methylenebisacrylamide. These hydrogels have been characterized by Fourier Transform infrared spectroscopy, thermo gravimetric analysis, swelling and drug release studies. The release of model drug rabeprazole sodium from the drug loaded hydrogels occurred through non-Fickian diffusion mechanism. Psyllium itself acts as anti-ulcer agent and release of rabeprazole from the drug loaded hydrogels may enhance the curing potential of the drug delivery device. The haemocompatibility was evaluated by studying the blood interactions with hydrogels with reference to thrombogenicity and haemolytic potential. Thrombogenicity results indicate that hydrogels are non-thrombogenic as the weight of clot formed and thrombus percentage for hydrogels was less than the positive control. The haemolytic index has been observed <5%. These observations indicate that these hydrogels are haemo-compatible and hence could be used for oral administration of antiulcer drugs.
本文讨论了通过化学方法在 N,N'-亚甲基双丙烯酰胺存在下制备的车前子-PVA 水凝胶的合成、表征和血液相容性行为。这些水凝胶通过傅里叶变换红外光谱、热重分析、溶胀和药物释放研究进行了表征。模型药物雷贝拉唑钠从载药水凝胶中的释放是通过非菲克扩散机制发生的。车前子本身具有抗溃疡作用，从载药水凝胶中释放雷贝拉唑可能会增强药物输送装置的治疗潜力。通过研究与血栓形成和溶血潜力相关的血液与水凝胶的相互作用来评估血液相容性。血栓形成结果表明，水凝胶是非血栓形成的，因为形成的血栓重量和水凝胶的血栓百分比均小于阳性对照。溶血指数观察到<5%。这些观察结果表明，这些水凝胶具有血液相容性，因此可用于口服抗溃疡药物。
