Department of Chemistry, Himachal Pradesh University, Shimla 171005, India.
Int J Biol Macromol. 2009 Nov 1;45(4):338-47. doi: 10.1016/j.ijbiomac.2009.08.001. Epub 2009 Aug 7.
Psyllium is a medicinally important polysaccharide and its modification with methacrylamide through radiation crosslinked polymerization will develop hydrogels meant for drug delivery applications. The present paper deals with the preparation of hydrogels and their characterization by SEMs, FTIR, TGA and swelling studies. The release dynamics of model antibiotic drug rifampicin from the hydrogels has been studied for the evaluation of the release mechanism. The values of the diffusion exponent 'n' have been obtained (0.64, 0.58 and 0.57), respectively, in distilled water, pH 2.2 buffer and pH 7.4 buffer. The release of the drug from the hydrogels occurred through non-Fickian diffusion mechanism.
洋车前子是一种具有重要药用价值的多糖，通过辐射交联聚合将其与丙烯酰胺进行修饰，将开发出用于药物输送应用的水凝胶。本文主要研究了水凝胶的制备及其通过 SEM、FTIR、TGA 和溶胀研究进行的表征。通过研究模型抗生素利福平从水凝胶中的释放动力学，评估了释放机制。在蒸馏水中、pH 2.2 缓冲液和 pH 7.4 缓冲液中，分别得到扩散指数 'n' 的值为（0.64、0.58 和 0.57）。药物从水凝胶中的释放是通过非菲克扩散机制发生的。
