调控长非编码 RNA 与神经疾病。
Regulatory long non-coding RNAs and neuronal disorders.
机构信息
Developmental Biology and Department of Pediatrics, Children's Memorial Hospital and Feinberg School of Medicine, Northwestern University, Box 204, 2430 N. Halsted, Chicago, IL 60614, United States.
出版信息
Physiol Behav. 2010 Jun 1;100(3):250-4. doi: 10.1016/j.physbeh.2010.01.015. Epub 2010 Jan 25.
Abstract
Increasing evidence suggests that GABA neuropathies play a major role in a variety of neuronal disorders. In addition, the role of non-coding RNAs in regulating a wide range of cellular processes is an intense area of investigation. This commentary discusses the intersection of these two fields, a corollary to the finding that adult hippocampal GABAergic interneuron development is controlled by an embryonic non-coding RNA during development.
摘要
越来越多的证据表明，GABA 能神经元病变在多种神经紊乱中起着重要作用。此外，非编码 RNA 在调节广泛的细胞过程中的作用是一个研究热点。这篇评论讨论了这两个领域的交叉，这是一个推论，即成年海马 GABA 能中间神经元的发育是由发育过程中的一种胚胎非编码 RNA 控制的。
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