静脉血栓栓塞症与癌症预后。
Venous thromboembolism and prognosis in cancer.
机构信息
James P. Wilmot Cancer Center, and the Department of Medicine, University of Rochester, Rochester, NY 14642, USA.
出版信息
Thromb Res. 2010 Jun;125(6):490-3. doi: 10.1016/j.thromres.2009.12.023. Epub 2010 Jan 25.
Abstract
Venous thromboembolism (VTE) is a frequent complication of malignancy, and its incidence has increased markedly in recent years. VTE itself can directly lead to patient mortality, and is the second leading cause of death in patients with cancer. Furthermore, emerging data suggest that activation of coagulation in malignancy is integrally linked with tumor biology, particularly with angiogenesis. The development of the clinical hypercoagulable state is also linked with adverse prognosis in patients with cancer, including patients receiving systemic chemotherapy. This review focuses on the clinical evidence documenting a link between VTE and adverse short-term and long-term prognosis in patients with cancer.
摘要
静脉血栓栓塞症（VTE）是恶性肿瘤的常见并发症，近年来其发病率显著增加。VTE 本身可直接导致患者死亡，是癌症患者死亡的第二大原因。此外，新出现的数据表明，恶性肿瘤中凝血的激活与肿瘤生物学密切相关，尤其是与血管生成有关。临床高凝状态的发展也与癌症患者的不良预后相关，包括接受全身化疗的患者。本综述重点介绍了 VTE 与癌症患者短期和长期预后不良之间关联的临床证据。
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