Jimbo Hiroyuki, Kamata Shinetsu, Miura Kouki, Asamoto Shunji, Tada Shinichiro, Endo Takahiro, Masubuchi Tatsuo, Nakamura Narihiro, Fushimi Chihiro
Skull Base Center, International University of Health and Welfare, Mita Hospital, Tokyo, Japan.
Neurol Med Chir (Tokyo). 2010 Jan;50(1):20-6; discussion 26. doi: 10.2176/nmc.50.20.
Cancers of the paranasal sinuses and nasal cavity are the most common malignant tumors of the anterior and anterolateral skull base. The treatment of these tumors affecting the skull base is complex due to the significant anatomical features. We examined 25 patients, 17 males and 8 females with mean age 61 +/- 2 years. En bloc resections using anterior skull base resection, orbital resection, middle fossa resection, and combined procedures of these three resections were performed. Using a combination of adjuvant radiation and chemotherapy, we have achieved a 2-year disease-free survival rate of 90% in these cases. However, potential complications include cerebrospinal fluid leakage, meningitis, abscess formation, pneumocephalus, frontal brain contusion, trismus, and dysphagia as a functional complication. We believe that the optimal management of such malignant tumors involves a multimodal and multidisciplinary team approach. Here we present our recent institutional experience and treatment policy employed during the past 3 years.
鼻窦和鼻腔癌是前颅底和前外侧颅底最常见的恶性肿瘤。由于显著的解剖学特征，这些影响颅底的肿瘤的治疗很复杂。我们检查了25例患者，其中男性17例，女性8例，平均年龄61±2岁。采用前颅底切除术、眼眶切除术、中颅窝切除术以及这三种切除术的联合手术进行整块切除。通过辅助放疗和化疗相结合，我们在这些病例中实现了2年无病生存率为90%。然而，潜在的并发症包括脑脊液漏、脑膜炎、脓肿形成、气颅、额叶脑挫伤、牙关紧闭和吞咽困难等功能并发症。我们认为，此类恶性肿瘤的最佳治疗方法需要多模式和多学科团队协作。在此，我们介绍我们机构最近在过去3年中的经验和采用的治疗策略。
