从碳水化合物中多米诺式合成高度取代的色满和异色满。
Domino access to highly substituted chromans and isochromans from carbohydrates.
作者信息
Leibeling Markus, Koester Dennis C, Pawliczek Martin, Schild Svenia C, Werz Daniel B
机构信息
Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Göttingen, Germany.
出版信息
Nat Chem Biol. 2010 Mar;6(3):199-201. doi: 10.1038/nchembio.302. Epub 2010 Jan 24.
Herein we describe the synthesis of highly substituted chromans and isochromans using carbohydrates as starting materials. Our approach makes use of a Pd-catalyzed domino reaction consisting of oxidative addition, followed by two carbopalladation steps and completed by a cyclization to annelate the benzene moiety. The versatility of this route has been demonstrated by a small library of highly substituted chromans and isochromans.
在此，我们描述了以碳水化合物为起始原料合成高度取代的色满和异色满的方法。我们的方法利用了钯催化的多米诺反应，该反应包括氧化加成，随后是两个碳钯化步骤，并通过环化反应来融合苯环部分而完成。这条路线的通用性已通过一个由高度取代的色满和异色满组成的小型文库得到了证明。
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