Aoyagi Keishiro, Kouhuji Kikuo, Yano Shojiro, Miyagi Motoshi, Imaizumi Takuya, Takeda Jinryo, Shirouzu Kazuo
Department of Surgery, Kurume University, School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, Japan.
Int Surg. 2009 Jan-Feb;94(1):1-9.
Here, we report the Ki-67 Labeling Index, the expression of c-kit, p53, bcl-2, and apoptosis in 11 gastrointestinal stromal tumors (GISTs). The Ki-67 Labeling Index in the malignant GIST group was higher than that in the benign group. The Ki-67 Labeling Index in the p53-positive cases was higher than that in the p53-negative cases. The Ki-67 Labeling Index in the C-kit-positive group was higher than that in the C-kit-negative group. The bcl-2 expression was not correlated with potential malignancy. The apoptotic count in the bcl-2-positive cases was higher than that in the bcl-2-negative cases. The Ki-67 Labeling Index, the p53 overexpression, and the C-kit expression were useful in predicting the potential malignancy.
在此，我们报告了11例胃肠道间质瘤（GIST）中Ki-67标记指数、c-kit、p53、bcl-2的表达及细胞凋亡情况。恶性GIST组的Ki-67标记指数高于良性组。p53阳性病例的Ki-67标记指数高于p53阴性病例。C-kit阳性组的Ki-67标记指数高于C-kit阴性组。bcl-2表达与潜在恶性程度无关。bcl-2阳性病例的凋亡计数高于bcl-2阴性病例。Ki-67标记指数、p53过表达及C-kit表达有助于预测潜在恶性程度。
