Multiple papillary fibroelastomas in rare locations of aortic valve and left ventricular outflow tract: a case report.

Papillary fibroelastoma (PFE) is the third most common primary neoplasm of the heart. The lesions generally appear singly, but multiple PFEs may rarely occur. The case is reported of multiple PFEs in a woman initially admitted for acute cerebral infarction. Echocardiography revealed four masses, one located on each cusp of the aortic valve and one on the left ventricular outflow tract. All four lesions were successfully removed surgically. An histopathologic examination revealed PFEs arising from the ventricular and valvular endocardium.