吸烟对体外受精治疗中卵巢功能及早期妊娠结局的影响。

The effect of cigarette smoking on ovarian function and early pregnancy outcome of in vitro fertilization treatment.

作者信息

Pattinson H A, Taylor P J, Pattinson M H

机构信息

In Vitro Fertilization Programme, Foothills Hospital/University of Calgary, Alberta, Canada.

出版信息

Fertil Steril. 1991 Apr;55(4):780-3. doi: 10.1016/s0015-0282(16)54248-4.

DOI:10.1016/s0015-0282(16)54248-4

PMID:2010004

Abstract

A retrospective analysis of the results of the first attempt at in vitro fertilization (IVF) treatment in 447 couples was performed by chart review. In 124 couples the female partners smoked cigarettes, and in 236 couples they did not. A total of 69 pregnancies (19.2%) were achieved, 50 in nonsmokers (21.2% per cycle), and 19 in smokers (15.3% per cycle). There were no significant differences in these cycles between the two groups in peak estradiol level achieved, the number of eggs retrieved, fertilization rate, or implantation rate. The incidence of spontaneous abortion was higher in smokers (42.1%) than in nonsmokers (18.9%). Consequently, the delivery rate per cycle of IVF was significantly lower in the smoking group (11 of 124, 9.6%) than in the nonsmokers (40 of 236, 17.0%). There was no effect when only the husband was a smoker. From these data, smoking appears to significantly reduce the chances of successful pregnancy after IVF treatment.

摘要

通过病历回顾对447对夫妇首次体外受精（IVF）治疗的结果进行了回顾性分析。124对夫妇中的女性伴侣吸烟，236对夫妇中的女性伴侣不吸烟。总共实现了69次妊娠（19.2%），不吸烟者中有50次（每个周期21.2%），吸烟者中有19次（每个周期15.3%）。两组在达到的峰值雌二醇水平、取出的卵子数量、受精率或着床率方面，这些周期没有显著差异。吸烟者的自然流产发生率（42.1%）高于不吸烟者（18.9%）。因此，吸烟组IVF每个周期的分娩率（124对中的11对，9.6%）显著低于不吸烟者（236对中的40对，17.0%）。仅丈夫吸烟时没有影响。根据这些数据，吸烟似乎会显著降低IVF治疗后成功妊娠的几率。