Department of Dermatology, Virgen Macarena University Hospital, Seville, Spain.
Dermatol Surg. 2010 Mar;36(3):363-7. doi: 10.1111/j.1524-4725.2009.01446.x. Epub 2010 Jan 19.
Epidermodysplasia verruciformis (EV) is a genodermatosis, characterized by human papilloma virus infection, with polymorphic and disseminated lesions that develop malignant transformation in approximately half of patients.
We describe clinical and epidemiological features of 10 cases of EV during a 5-year period. All were treated using curettage of the nonmalignant wart-like lesions with a curette and application of 35% trichloroacetic acid (TCA) with a cotton bud for a few seconds.
Ten patients aged 33 to 67, nine women and one man, were treated, mainly presenting flat, brownish, wart-like lesions distributed on the anterior and posterior trunk. Two patients developed squamous cell carcinoma, histologically confirmed, that was surgically removed using fusiform excision. Good cosmetic results were obtained, and there was no reappearance of lesions during a mean follow-up of 3.5 years.
Curettage and application of 35% TCA that we have used in these patients has been shown to be an effective and low-cost alternative, compared to oral, topical, or other physical ablative therapies, with satisfactory cosmetic results and no recurrence during follow-up.
疣状表皮发育不良（EV）是一种遗传性皮肤病，其特征是人类乳头瘤病毒感染，具有多形性和播散性病变，约有一半的患者会发生恶性转化。
我们描述了 5 年内 10 例 EV 的临床和流行病学特征。所有患者均采用刮匙刮除非恶性疣状病变，并用棉签蘸 35%三氯乙酸（TCA）涂擦数秒进行治疗。
10 例患者年龄 33 至 67 岁，9 例为女性，1 例为男性，主要表现为分布在前胸和后背的扁平、褐色、疣状病变。2 例患者发生鳞状细胞癌，经组织学证实，并采用梭形切除术切除。获得了良好的美容效果，平均随访 3.5 年未见病变复发。
与口服、局部或其他物理消融治疗相比，我们在这些患者中使用的刮除术联合 35%TCA 涂抹具有疗效确切、费用低廉的优势，且美容效果满意，随访期间无复发。
