Gurudutt Vivek V, Genden Eric M
Department of Otolaryngology-Head and Neck Surgery, Mount Sinai School of Medicine, 5 East 98th Street, 8th Floor, New York, NY 10029, USA.
J Skin Cancer. 2011;2011:502723. doi: 10.1155/2011/502723. Epub 2011 Feb 21.
Cutaneous squamous cell carcinoma of the head and neck is an epidemic that reaches all parts of the world. Making the diagnosis relies on the acumen of the clinician and pathologist. Various pathologic subtypes exist and differ in histology and prognosis. High-risk tumors need aggressive treatment and vigilant surveillance to monitor for recurrence. Large tumors, deep tissue invasion, perineural involvement, recurrence, location in high-risk areas, and immunosuppression are implicated in worsening prognosis. Surgery is the mainstay of treatment with adjuvant radiation therapy as needed for aggressive tumors; however, other modalities are potentially useful for low-risk lesions. The use of Mohs surgery has become increasingly useful and has shown high success rates. Involvement of parotid and neck lymph nodes significantly affects outcomes and the physician should be comfortable with management of this complex disease. This paper examines the diagnosis, pathology, clinical course, and treatment options for cutaneous squamous cell carcinoma of the head and neck.
头颈部皮肤鳞状细胞癌是一种在世界各地都有流行的疾病。做出诊断依赖于临床医生和病理学家的敏锐洞察力。存在多种病理亚型，它们在组织学和预后方面有所不同。高危肿瘤需要积极治疗并进行密切监测以监测复发情况。大肿瘤、深部组织浸润、神经周围侵犯、复发、高危区域的位置以及免疫抑制都与预后恶化有关。手术是主要的治疗方法，对于侵袭性肿瘤根据需要辅助放射治疗；然而，其他治疗方式对低风险病变可能也有用。莫氏手术的应用越来越广泛且已显示出高成功率。腮腺和颈部淋巴结受累会显著影响治疗结果，医生应熟悉这种复杂疾病的管理。本文探讨了头颈部皮肤鳞状细胞癌的诊断、病理、临床病程及治疗选择。
