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Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia.胰腺导管腺是独特的导管隔室，对慢性损伤有反应，并介导 Shh 诱导的化生。
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Pancreatic ductal adenocarcinoma: tumor microenvironment and problems in the development of novel therapeutic strategies.胰腺导管腺癌：肿瘤微环境与新型治疗策略开发中的问题。
Clin Exp Med. 2023 Jul;23(3):619-643. doi: 10.1007/s10238-022-00886-1. Epub 2022 Sep 9.
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Robust Validation and Comprehensive Analysis of a Novel Signature Derived from Crucial Metabolic Pathways of Pancreatic Ductal Adenocarcinoma.源于胰腺导管腺癌关键代谢途径的新型特征的稳健验证与综合分析
Cancers (Basel). 2022 Apr 4;14(7):1825. doi: 10.3390/cancers14071825.
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Tumor-stromal crosstalk in pancreatic cancer and tissue fibrosis.胰腺癌中的肿瘤-基质相互作用与组织纤维化。
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Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreas.Sonic Hedgehog（Shh）异位过表达诱导成年小鼠胰腺基质扩张和化生。
Neoplasia. 2011 Oct;13(10):923-30. doi: 10.1593/neo.11088.

本文引用的文献

1
Pancreatic duct glands are distinct ductal compartments that react to chronic injury and mediate Shh-induced metaplasia.胰腺导管腺是独特的导管隔室，对慢性损伤有反应，并介导 Shh 诱导的化生。
Gastroenterology. 2010 Mar;138(3):1166-77. doi: 10.1053/j.gastro.2009.12.005. Epub 2009 Dec 21.
2
Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas.成年鼠胰腺中心腺泡/终末导管祖细胞的分离与鉴定。
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):75-80. doi: 10.1073/pnas.0912589107. Epub 2009 Dec 15.
3
The hedgehog pathway and pancreatic cancer.刺猬信号通路与胰腺癌
N Engl J Med. 2009 Nov 19;361(21):2094-6. doi: 10.1056/NEJMcibr0905857.
4
Mucin-producing neoplasms of the pancreas: an analysis of distinguishing clinical and epidemiologic characteristics.胰腺黏液性产肿瘤：临床和流行病学特征分析。
Clin Gastroenterol Hepatol. 2010 Feb;8(2):213-9. doi: 10.1016/j.cgh.2009.10.001. Epub 2009 Oct 14.
5
Combined targeted treatment to eliminate tumorigenic cancer stem cells in human pancreatic cancer.联合靶向治疗以消除人胰腺癌中的致瘤性癌症干细胞。
Gastroenterology. 2009 Sep;137(3):1102-13. doi: 10.1053/j.gastro.2009.05.053. Epub 2009 Jun 6.
6
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer.在胰腺癌小鼠模型中，抑制刺猬信号通路可增强化疗药物的递送。
Science. 2009 Jun 12;324(5933):1457-61. doi: 10.1126/science.1171362. Epub 2009 May 21.
7
Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning.胃和肠道中的旁分泌刺猬信号通路：刺猬信号在胃肠道模式形成中的新作用
Gastroenterology. 2009 Aug;137(2):618-28. doi: 10.1053/j.gastro.2009.05.002. Epub 2009 May 13.
8
Cystic lesions and intraductal neoplasms of the pancreas.胰腺囊性病变及导管内肿瘤
Best Pract Res Clin Gastroenterol. 2009;23(1):35-48. doi: 10.1016/j.bpg.2008.11.011.
9
Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth.碳酸酐酶II阳性的胰腺细胞是出生后内分泌和外分泌胰腺的祖细胞。
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19915-9. doi: 10.1073/pnas.0805803105. Epub 2008 Dec 3.
10
Sonic hedgehog promotes desmoplasia in pancreatic cancer.音猬因子促进胰腺癌的促结缔组织增生反应。
Clin Cancer Res. 2008 Oct 1;14(19):5995-6004. doi: 10.1158/1078-0432.CCR-08-0291.

Tracking down the hedgehog's lair in the pancreas.

作者信息

Maitra Anirban

出版信息

Gastroenterology. 2010 Mar;138(3):823-5. doi: 10.1053/j.gastro.2010.01.021. Epub 2010 Jan 25.

DOI:10.1053/j.gastro.2010.01.021
PMID:20100446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3025814/
Abstract
摘要