I.R.C.C.S. Istituto Ortopedico Galeazzi, Milano, Italy.
Clin Chim Acta. 2010 May 2;411(9-10):645-8. doi: 10.1016/j.cca.2010.01.021. Epub 2010 Jan 25.
Uric acid (UA), a major plasmatic antioxidant is an intracellular scavenger, especially during metabolic stress. UA serum concentration could be important for evaluating oxidant stress and the correspondent response in sportsmen, who are prone to the risk of oxidant increase and related cell and tissue damage.
Blood was collected from 10 male and 8 female alpine skiers from the Italian National Team (current age range, 26-33 and 24-28 years, respectively) over an entire season. The analyses were performed using an uricase-based enzymatic method.
Mean UA values were 3.8 mg/dl in females and 4.8 mg/dl in males: a significant difference between genders was maintained across all four competitive seasons. No differences emerged within either gender during each season nor between different intra-seasonal or inter-seasonal blood drawings in individual athletes.
Our results suggest that serum UA in top-level athletes is a stable parameter. High-intensity workload caused serum UA changes lower than biological variability both within the competitive season or between different seasons. Serum UA increased immediately after exercise, but the resting concentration was not influenced by sports activity. The data of our study showed that this parameter is not useful for marking high physical demand or overtraining.
尿酸（UA）是一种主要的血浆抗氧化剂，是一种细胞内清除剂，特别是在代谢应激期间。UA 血清浓度对于评估运动员的氧化应激和相应反应可能很重要，因为运动员容易面临氧化增加的风险，以及相关的细胞和组织损伤。
从意大利国家队的 10 名男性和 8 名女性高山滑雪运动员（当前年龄范围分别为 26-33 岁和 24-28 岁）整个赛季中采集血液。使用尿酸酶法进行分析。
女性的平均 UA 值为 3.8mg/dl，男性为 4.8mg/dl：性别之间存在显著差异，在所有四个竞技赛季中均保持不变。在每个赛季内，无论是在同一性别内还是在不同的赛季内或个体运动员的不同赛季间采血，均未出现差异。
我们的结果表明，高水平运动员的血清 UA 是一个稳定的参数。高强度的工作量导致血清 UA 变化低于竞争赛季内或不同赛季之间的生物学变异性。运动后血清 UA 立即升高，但静息浓度不受运动活动的影响。我们研究的数据表明，该参数对于标记高身体需求或过度训练并不有用。
