Grupo de Canabinoides, Depto. de Fisiología, Fac. de Medicina, UNAM, México, D.F. 04510, Mexico.
Pharmacol Res. 2010 May;61(5):379-84. doi: 10.1016/j.phrs.2010.01.010. Epub 2010 Jan 25.
Oleoylethanolamide (OEA) is an endogenous molecule related to endocannabinoids (eCBs) that induces satiety. It binds to the peroxisome-proliferator-activated receptor alpha (PPAR alpha). PPAR alpha is involved in feeding regulation and it has been proposed to play a role in sleep modulation. The objective of the present work is to show if this molecule modifies the sleep-waking cycle through central mechanisms. We have found that the peripheral administration of OEA reduces food intake and increases waking with a concomitant reduction of rapid eye movement sleep. Additionally, this treatment produces deactivation of the lateral hypothalamus, as inferred from the c-Fos expression evaluation. Finally, intra-lateral hypothalamus injection of OEA has mirrored the effects induced by this molecule when it is peripherally administered. In conclusion, we show for the very first time that OEA can modify the sleep-waking cycle and food intake, apparently mediated by the lateral hypothalamus.
油酰乙醇酰胺（OEA）是一种与内源性大麻素（eCBs）相关的内源性分子，能诱导饱腹感。它与过氧化物酶体增殖物激活受体-α（PPARα）结合。PPARα 参与进食调节，据推测它在睡眠调节中发挥作用。本工作的目的是通过中枢机制显示这种分子是否能改变睡眠-觉醒周期。我们发现，OEA 的外周给药可减少食物摄入并增加觉醒，同时减少快速眼动睡眠。此外，通过 c-Fos 表达评估推断，这种治疗会使外侧下丘脑失活。最后，OEA 内侧下丘脑内注射反映了该分子外周给药时所诱导的作用。总之，我们首次表明，OEA 可以通过外侧下丘脑明显调节睡眠-觉醒周期和摄食。
