R. M. Alden Research Laboratory, 6133 Bristol Parkway, Suite 175, Culver City, CA 90404, USA.
Antimicrob Agents Chemother. 2010 Apr;54(4):1627-32. doi: 10.1128/AAC.01788-09. Epub 2010 Jan 25.
The in vitro activities of ceftaroline, a novel, parenteral, broad-spectrum cephalosporin, and four comparator antimicrobials were determined against anaerobic bacteria. Against Gram-positive strains, the activity of ceftaroline was similar to that of amoxicillin-clavulanate and four to eight times greater than that of ceftriaxone. Against Gram-negative organisms, ceftaroline showed good activity against beta-lactamase-negative strains but not against the members of the Bacteroides fragilis group. Ceftaroline showed potent activity against a broad spectrum of anaerobes encountered in respiratory, skin, and soft tissue infections.
我们测定了新型的、注射用、广谱头孢菌素头孢洛林的体外活性,以及四种对照抗菌药物对厌氧菌的活性。与革兰阳性菌相比,头孢洛林的活性与阿莫西林-克拉维酸相似,是头孢曲松的 4 至 8 倍。对于革兰氏阴性菌,头孢洛林对β-内酰胺酶阴性菌株具有良好的活性,但对脆弱拟杆菌群的成员没有活性。头孢洛林对呼吸道、皮肤和软组织感染中遇到的广泛的厌氧菌具有很强的活性。