头孢洛林对 623 株不同种属的厌氧细菌的体外活性研究。
In vitro activity of ceftaroline against 623 diverse strains of anaerobic bacteria.
机构信息
R. M. Alden Research Laboratory, 6133 Bristol Parkway, Suite 175, Culver City, CA 90404, USA.
出版信息
Antimicrob Agents Chemother. 2010 Apr;54(4):1627-32. doi: 10.1128/AAC.01788-09. Epub 2010 Jan 25.
Abstract
The in vitro activities of ceftaroline, a novel, parenteral, broad-spectrum cephalosporin, and four comparator antimicrobials were determined against anaerobic bacteria. Against Gram-positive strains, the activity of ceftaroline was similar to that of amoxicillin-clavulanate and four to eight times greater than that of ceftriaxone. Against Gram-negative organisms, ceftaroline showed good activity against beta-lactamase-negative strains but not against the members of the Bacteroides fragilis group. Ceftaroline showed potent activity against a broad spectrum of anaerobes encountered in respiratory, skin, and soft tissue infections.
摘要
我们测定了新型的、注射用、广谱头孢菌素头孢洛林的体外活性，以及四种对照抗菌药物对厌氧菌的活性。与革兰阳性菌相比，头孢洛林的活性与阿莫西林-克拉维酸相似，是头孢曲松的 4 至 8 倍。对于革兰氏阴性菌，头孢洛林对β-内酰胺酶阴性菌株具有良好的活性，但对脆弱拟杆菌群的成员没有活性。头孢洛林对呼吸道、皮肤和软组织感染中遇到的广泛的厌氧菌具有很强的活性。
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