University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh 160014, India.
Neurosci Bull. 2010 Feb;26(1):17-27. doi: 10.1007/s12264-010-0713-x.
Cyclooxygenase isoenzyme is known to be expressed in different regions of brain, and is mainly used for the treatment of pain and inflammation. Recently, it is proposed that cyclooxygenase isoenzyme may also play a key role in the pathophysiology of various brain-related disorders. The present study was aimed to explore the protective effect of cyclooxygenase inhibitors on stress by using an animal model of chronic stress.
The animals were forced to swim individually for a period of 6 min every day for 15 d. Then, the behavior (locomotor activity, anxiety and memory) and biochemical (lipid peroxidation, nitrite level, reduced glutathione, and catalase) alterations were assessed.
Forced swimming for 15 d caused impaired locomotor activity, anxiety-like behavior and decreased percentage of memory retention, as compared to naive mice (without chronic fatigue treatment). Biochemical analysis revealed significant increases in lipid peroxidation and nitrite level, while levels of reduced glutathione and catalase activity were both decreased. Chronic treatment with naproxen (14 mg/kg, i.p.), rofecoxib (5 mg/kg, i.p.), meloxicam (5 mg/kg, i.p.), nimesulide (5 mg/kg, i.p.) and valdecoxib (10 mg/kg, i.p.) significantly attenuated these behavioral and biochemical (oxidative damage) alterations in chronic-stressed mice.
The cyclooxygenase inhibitors could be used in the management of chronic fatigue-like conditions.
环氧化酶同工酶已知在大脑的不同区域表达，主要用于治疗疼痛和炎症。最近，有人提出环氧化酶同工酶也可能在各种与大脑相关的疾病的病理生理学中发挥关键作用。本研究旨在通过使用慢性应激动物模型来探索环氧化酶抑制剂对应激的保护作用。
动物每天被迫单独游泳 6 分钟，持续 15 天。然后评估行为（运动活动、焦虑和记忆）和生化（脂质过氧化、亚硝酸盐水平、还原型谷胱甘肽和过氧化氢酶）变化。
与未接受慢性疲劳治疗的对照（无慢性疲劳处理）相比，15 天的强迫游泳导致运动活动受损、焦虑样行为和记忆保留百分比降低。生化分析显示脂质过氧化和亚硝酸盐水平显著升高，而还原型谷胱甘肽和过氧化氢酶活性水平均降低。萘普生（14mg/kg，腹腔注射）、罗非昔布（5mg/kg，腹腔注射）、美洛昔康（5mg/kg，腹腔注射）、尼美舒利（5mg/kg，腹腔注射）和伐地昔布（10mg/kg，腹腔注射）的慢性治疗显著减轻了慢性应激小鼠的这些行为和生化（氧化损伤）改变。
环氧化酶抑制剂可用于管理慢性疲劳样疾病。
