前列腺素 E2 受体 EP 亚型在阿尔茨海默病中的作用。
Roles of the prostaglandin E2 receptors EP subtypes in Alzheimer's disease.
机构信息
Department of Mental Health, Sir Run Run Shaw Hospital, Zhejiang University Medical School, Hangzhou 310016,China.
出版信息
Neurosci Bull. 2010 Feb;26(1):77-84. doi: 10.1007/s12264-010-0703-z.
Abstract
Neuroinflammation has always been of concern in the pathogenesis of Alzheimer's disease (AD). As a major inflammatory mediator, prostaglandin E(2) (PGE(2)) plays an important role in the inflammatory process of AD. Up to now, there is still controversy on the neuroprotective or neurotoxic role of PGE(2). However, the role of PGE(2) in neurodegeneration may be far more complex, due to the 4 EP receptor subtypes. This article aims to summarize the relationship between PGE(2) receptor EP subtypes and AD. It is believed that a better understanding of the PGE(2) receptor EP subtypes may help to clarify the relation between inflammation and AD, and to develop novel therapeutic strategies targeting specific EP receptor for AD treatment.
摘要
神经炎症一直是阿尔茨海默病（AD）发病机制中的关注点。作为主要的炎症介质，前列腺素 E（2）（PGE（2））在 AD 的炎症过程中起着重要作用。到目前为止，关于 PGE（2）的神经保护或神经毒性作用仍存在争议。然而，由于存在 4 种 EP 受体亚型，PGE（2）在神经退行性变中的作用可能更为复杂。本文旨在总结 PGE（2）受体 EP 亚型与 AD 之间的关系。相信更好地了解 PGE（2）受体 EP 亚型可能有助于阐明炎症与 AD 之间的关系，并开发针对 AD 治疗的特定 EP 受体的新型治疗策略。
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