喹硫磷对小鼠的细胞遗传学效应。

Cytogenetic effects of quinalphos in mice.

作者信息

Rupa D S, Reddy P P, Reddi O S

机构信息

Department of Biomedical and Environmental Health Sciences, School of Public Health, University of California, Berkeley 94720.

出版信息

Food Chem Toxicol. 1991 Feb;29(2):115-7. doi: 10.1016/0278-6915(91)90165-4.

DOI:10.1016/0278-6915(91)90165-4

PMID:2010140

Abstract

The cytogenetic effect of quinalphos was studied in Swiss albino mice using the micronucleus test, bone marrow and germ cell chromosome assays and sperm morphology assay. Quinalphos at 5, 10 and 15 mg/kg body weight was administered orally to mice. Quinalphos induced micronuclei in the bone-marrow cells of mice and also caused a significant increase in chromosomal aberrations in bone-marrow cells (at 10 and 15 mg/kg body weight dose levels) and in germ cells (at all tested doses). A high incidence of abnormal sperms was also observed in mice treated with quinalphos.

摘要

使用微核试验、骨髓和生殖细胞染色体分析以及精子形态分析，研究了喹硫磷对瑞士白化小鼠的细胞遗传学效应。以5、10和15毫克/千克体重的剂量给小鼠口服喹硫磷。喹硫磷可诱导小鼠骨髓细胞产生微核，还会导致骨髓细胞（在10和15毫克/千克体重剂量水平）和生殖细胞（在所有测试剂量下）的染色体畸变显著增加。在用喹硫磷处理的小鼠中还观察到高比例的异常精子。