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二硫代氨基甲酸盐类杀菌剂Cuman L的细胞遗传学效应

Cytogenetic effects of Cuman L, a dithiocarbamate fungicide.

作者信息

Hemavathy K C, Krishnamurthy N B

机构信息

Department of Postgraduate Studies and Research in Zoology, University of Mysore, India.

出版信息

Mutat Res. 1988 May;208(1):57-60. doi: 10.1016/0165-7992(88)90021-8.

Abstract

Cuman L, a dithiocarbamate fungicide, was assessed for its effects in the germ cells and the bone marrow erythrocytes of Swiss Albino male mice. The 3 sublethal doses of 350, 700 and 1050 mg/kg b.w. of Cuman L induced a significant (P less than 0.01) increase in the number of chromosomal aberrations in the germ cells. A significant increase (P less than 0.01) in the percentage of micronuclei in the erythrocytes was also induced by the three doses.

摘要

对二硫代氨基甲酸盐类杀菌剂克菌丹(Cuman L)在瑞士白化雄性小鼠的生殖细胞和骨髓红细胞中的作用进行了评估。克菌丹(Cuman L)的3个亚致死剂量,即350、700和1050毫克/千克体重,可导致生殖细胞中染色体畸变数量显著增加(P<0.01)。这三个剂量还可导致红细胞中微核百分比显著增加(P<0.01)。

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