School of Psychology, CIPsi, University of Minho, Braga, Portugal.
J Autism Dev Disord. 2010 Jul;40(7):870-7. doi: 10.1007/s10803-010-0940-z.
Williams Syndrome (WS) is described as displaying a dissociation within memory systems. As the integrity of hippocampal formation (HF) is determinant for memory performance, we examined HF volumes and its association with memory measures in a group of WS and in a typically development group. A significantly reduced intracranial content was found in WS, despite no differences were observed for HF absolute volumes between groups. When volumes were normalized, left HF was increased in WS. Moreover, a lack of the normal right > left HF asymmetry was observed in WS. No positive correlations were found between volumetric and neurocognitive data in WS. In sum, a relative enlargement of HF and atypical patterns of asymmetry suggest abnormal brain development in WS.
威廉姆斯综合征（WS）被描述为在记忆系统中表现出分离。由于海马结构（HF）的完整性对记忆表现起决定性作用，我们研究了一组 WS 患者和一组典型发育组的 HF 体积及其与记忆测量的关系。尽管两组之间 HF 的绝对体积没有差异，但在 WS 中发现颅内内容物明显减少。当体积归一化时，WS 左侧 HF 增加。此外，在 WS 中观察到右 HF 正常>左 HF 不对称的缺失。在 WS 中，未发现体积和神经认知数据之间存在正相关关系。总之，HF 的相对增大和不对称模式的异常提示 WS 中存在异常的大脑发育。
