无药物大分子治疗学：通过细胞表面抗原卷曲螺旋介导的交联诱导细胞凋亡。
Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface.
机构信息
Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
出版信息
Angew Chem Int Ed Engl. 2010 Feb 15;49(8):1451-5. doi: 10.1002/anie.200906232.
Abstract
A new paradigm was designed for apoptosis induction mediated by the biorecognition of coiled-coil motifs at the Raji B cell surface. The heterodimerization of complementary peptides, one bound to Fab’ antibody fragment, the other as grafts to HPMA copolymer, results in crosslinking of CD20 target antigens, and consequently, initiation of apoptosis.
摘要
设计了一种新的范式，用于通过 Raji B 细胞表面卷曲螺旋基序的生物识别来诱导细胞凋亡。互补肽的异二聚化，一个结合到 Fab' 抗体片段上，另一个作为 HPMA 共聚物的接枝物，导致 CD20 靶抗原交联，从而启动细胞凋亡。
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