• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

无药物大分子治疗学：通过细胞表面抗原卷曲螺旋介导的交联诱导细胞凋亡。

Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface.

机构信息

Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA.

出版信息

Angew Chem Int Ed Engl. 2010 Feb 15;49(8):1451-5. doi: 10.1002/anie.200906232.

DOI:10.1002/anie.200906232
PMID:20101660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2998410/
Abstract

A new paradigm was designed for apoptosis induction mediated by the biorecognition of coiled-coil motifs at the Raji B cell surface. The heterodimerization of complementary peptides, one bound to Fab’ antibody fragment, the other as grafts to HPMA copolymer, results in crosslinking of CD20 target antigens, and consequently, initiation of apoptosis.

摘要

设计了一种新的范式，用于通过 Raji B 细胞表面卷曲螺旋基序的生物识别来诱导细胞凋亡。互补肽的异二聚化，一个结合到 Fab' 抗体片段上，另一个作为 HPMA 共聚物的接枝物，导致 CD20 靶抗原交联，从而启动细胞凋亡。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/2998410/415719cda814/nihms-254949-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/2998410/3f98a820e909/nihms-254949-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/2998410/534564262cd8/nihms-254949-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/2998410/e513924b9223/nihms-254949-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/2998410/8e56fa2ac6b1/nihms-254949-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/2998410/415719cda814/nihms-254949-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/2998410/3f98a820e909/nihms-254949-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/2998410/534564262cd8/nihms-254949-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/2998410/e513924b9223/nihms-254949-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/2998410/8e56fa2ac6b1/nihms-254949-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de14/2998410/415719cda814/nihms-254949-f0006.jpg

相似文献

1
Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface.无药物大分子治疗学：通过细胞表面抗原卷曲螺旋介导的交联诱导细胞凋亡。
Angew Chem Int Ed Engl. 2010 Feb 15;49(8):1451-5. doi: 10.1002/anie.200906232.
2
Human Serum Albumin-Based Drug-Free Macromolecular Therapeutics: Apoptosis Induction by Coiled-Coil-Mediated Cross-Linking of CD20 Antigens on Lymphoma B Cell Surface.基于人血清白蛋白的无药物大分子治疗药物：通过卷曲螺旋介导的淋巴瘤 B 细胞表面 CD20 抗原交联诱导细胞凋亡。
Macromol Biosci. 2018 Nov;18(11):e1800224. doi: 10.1002/mabi.201800224. Epub 2018 Sep 27.
3
Tuning assembly size in Peptide-based supramolecular polymers by modulation of subunit association affinity.通过调节亚基缔合亲和力来调整基于肽的超分子聚合物的组装尺寸。
Biomacromolecules. 2014 Apr 14;15(4):1436-42. doi: 10.1021/bm5000423. Epub 2014 Mar 17.
4
Amplification of CD20 Cross-Linking in Rituximab-Resistant B-Lymphoma Cells Enhances Apoptosis Induction by Drug-Free Macromolecular Therapeutics.利妥昔单抗耐药 B 淋巴细胞瘤细胞中 CD20 交联的扩增增强了无药物大分子治疗药物诱导的细胞凋亡。
ACS Nano. 2018 Apr 24;12(4):3658-3670. doi: 10.1021/acsnano.8b00797. Epub 2018 Apr 2.
5
Development of a series of cross-linking agents that effectively stabilize alpha-helical structures in various short peptides.开发一系列能有效稳定各种短肽中α-螺旋结构的交联剂。
Chemistry. 2008;14(3):857-63. doi: 10.1002/chem.200700843.
6
Hantavirus nucleocapsid protein coiled-coil domains.汉坦病毒核衣壳蛋白卷曲螺旋结构域
J Biol Chem. 2002 Jul 26;277(30):27103-8. doi: 10.1074/jbc.M203395200. Epub 2002 May 17.
7
Photo-control of peptide helix content by an azobenzene cross-linker: steric interactions with underlying residues are not critical.通过偶氮苯交联剂对肽螺旋含量进行光控：与潜在残基的空间相互作用并不关键。
Protein Eng. 2002 Jul;15(7):561-9. doi: 10.1093/protein/15.7.561.
8
A water-soluble azobenzene cross-linker for photocontrol of peptide conformation.一种用于光控肽构象的水溶性偶氮苯交联剂。
Bioconjug Chem. 2003 Jul-Aug;14(4):824-9. doi: 10.1021/bc0340161.
9
Plasmodium falciparum merozoite surface protein 6 (MSP-6) derived peptides bind erythrocytes and partially inhibit parasite invasion.恶性疟原虫裂殖子表面蛋白6（MSP-6）衍生肽可结合红细胞并部分抑制寄生虫入侵。
Peptides. 2006 Jul;27(7):1685-92. doi: 10.1016/j.peptides.2006.02.001. Epub 2006 May 19.
10
Conjugation of a novel Apaf-1 inhibitor to peptide-based cell-membrane transporters: effective methods to improve inhibition of mitochondria-mediated apoptosis.一种新型Apaf-1抑制剂与基于肽的细胞膜转运体的偶联：改善线粒体介导的细胞凋亡抑制作用的有效方法。
Peptides. 2007 May;28(5):958-68. doi: 10.1016/j.peptides.2007.02.014. Epub 2007 Mar 3.

引用本文的文献

1
Antigenic peptide delivery to antigen-presenting cells using a CD40-coiled coil affinity-based platform.利用基于CD40-卷曲螺旋亲和力的平台将抗原肽递送至抗原呈递细胞。
Drug Deliv. 2025 Dec;32(1):2486340. doi: 10.1080/10717544.2025.2486340. Epub 2025 May 26.
2
Combination of multivalent DR5 receptor clustering agonists and histone deacetylase inhibitors for treatment of colon cancer.多价DR5受体聚集激动剂与组蛋白去乙酰化酶抑制剂联合用于治疗结肠癌。
J Control Release. 2024 Dec;376:1014-1024. doi: 10.1016/j.jconrel.2024.10.062. Epub 2024 Nov 8.
3
Hydrophilic biomaterials: From crosslinked and self-assembled hydrogels to polymer-drug conjugates and drug-free macromolecular therapeutics.

本文引用的文献

1
HPMA copolymers: origins, early developments, present, and future.HPMA 共聚物：起源、早期发展、现状和未来。
Adv Drug Deliv Rev. 2010 Feb 17;62(2):122-49. doi: 10.1016/j.addr.2009.10.004. Epub 2009 Nov 14.
2
Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20.靶向B细胞抗原CD20的多价支链HPMA共聚物-Fab'缀合物的合成与评价
Bioconjug Chem. 2009 Jan;20(1):129-37. doi: 10.1021/bc800351m.
3
Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers.
亲水性生物材料：从交联和自组装水凝胶到聚合物药物偶联物和无药物的高分子治疗剂。
J Control Release. 2024 Sep;373:1-22. doi: 10.1016/j.jconrel.2024.05.012. Epub 2024 May 17.
4
Cell surface patching via CXCR4-targeted nanothreads for cancer metastasis inhibition.通过靶向 CXCR4 的纳米线进行细胞表面修补以抑制癌症转移。
Nat Commun. 2024 Mar 29;15(1):2763. doi: 10.1038/s41467-024-47111-z.
5
Multi-targeted immunotherapeutics to treat B cell malignancies.多靶点免疫疗法治疗 B 细胞恶性肿瘤。
J Control Release. 2023 Jun;358:232-258. doi: 10.1016/j.jconrel.2023.04.048. Epub 2023 May 5.
6
Tumor Marker B7-H6 Bound to the Coiled Coil Peptide-Polymer Conjugate Enables Targeted Therapy by Activating Human Natural Killer Cells.与卷曲螺旋肽-聚合物缀合物结合的肿瘤标志物B7-H6通过激活人类自然杀伤细胞实现靶向治疗。
Biomedicines. 2021 Nov 2;9(11):1597. doi: 10.3390/biomedicines9111597.
7
Neurosurgery at the crossroads of immunology and nanotechnology. New reality in the COVID-19 pandemic.神经外科学处于免疫学和纳米技术的十字路口。COVID-19 大流行中的新现实。
Adv Drug Deliv Rev. 2022 Feb;181:114033. doi: 10.1016/j.addr.2021.114033. Epub 2021 Nov 20.
8
Supramolecular "Click Chemistry" for Targeting in the Body.基于超分子“点击化学”的靶向给药研究
Bioconjug Chem. 2021 Sep 15;32(9):1935-1946. doi: 10.1021/acs.bioconjchem.1c00326. Epub 2021 Aug 20.
9
Crosslinking of CD38 Receptors Triggers Apoptosis of Malignant B Cells.交联 CD38 受体触发恶性 B 细胞凋亡。
Molecules. 2021 Jul 31;26(15):4658. doi: 10.3390/molecules26154658.
10
Supramolecular polymerization of sulfated dendritic peptide amphiphiles into multivalent L-selectin binders.硫酸化树枝状肽两亲分子超分子聚合成多价L-选择素结合剂。
Beilstein J Org Chem. 2021 Jan 12;17:97-104. doi: 10.3762/bjoc.17.10. eCollection 2021.
聚甲基丙烯酸羟丙酯杂化接枝共聚物自组装的动态光散射研究
Biomacromolecules. 2008 Feb;9(2):510-7. doi: 10.1021/bm701001f. Epub 2008 Jan 22.
4
Hydrogel biomaterials: a smart future?水凝胶生物材料：智能的未来？
Biomaterials. 2007 Dec;28(34):5185-92. doi: 10.1016/j.biomaterials.2007.07.044. Epub 2007 Aug 13.
5
Two-step fluorescence screening of CD21-binding peptides with one-bead one-compound library and investigation of binding properties of N-(2-hydroxypropyl)methacrylamide copolymer-peptide conjugates.使用单珠单化合物文库对CD21结合肽进行两步荧光筛选以及对N-(2-羟丙基)甲基丙烯酰胺共聚物-肽缀合物的结合特性进行研究。
Biomacromolecules. 2006 Nov;7(11):3037-46. doi: 10.1021/bm060508f.
6
Refolding hydrogels self-assembled from N-(2-hydroxypropyl)methacrylamide graft copolymers by antiparallel coiled-coil formation.通过反平行卷曲螺旋形成由N-（2-羟丙基）甲基丙烯酰胺接枝共聚物自组装的复性水凝胶。
Biomacromolecules. 2006 Apr;7(4):1187-95. doi: 10.1021/bm051002k.
7
Identification of CD21-binding peptides with phage display and investigation of binding properties of HPMA copolymer-peptide conjugates.利用噬菌体展示技术鉴定CD21结合肽并研究HPMA共聚物-肽缀合物的结合特性。
Bioconjug Chem. 2006 Mar-Apr;17(2):514-23. doi: 10.1021/bc0503162.
8
Generation of rituximab polymer may cause hyper-cross-linking-induced apoptosis in non-Hodgkin's lymphomas.利妥昔单抗聚合物的生成可能会在非霍奇金淋巴瘤中引发超交联诱导的细胞凋亡。
Clin Cancer Res. 2005 Aug 15;11(16):5971-80. doi: 10.1158/1078-0432.CCR-05-0554.
9
Smart and genetically engineered biomaterials and drug delivery systems.智能与基因工程生物材料及药物递送系统
Eur J Pharm Sci. 2003 Sep;20(1):1-16. doi: 10.1016/s0928-0987(03)00164-7.
10
CD20-mediated apoptosis: signalling through lipid rafts.CD20介导的细胞凋亡：通过脂筏进行信号传导。
Immunology. 2002 Oct;107(2):176-82. doi: 10.1046/j.1365-2567.2002.01495.x.