Department of Obstetrics and Gynaecology, University Hospital of Heraklion, Crete, Greece.
Prenat Diagn. 2010 Mar;30(3):212-5. doi: 10.1002/pd.2438.
To investigate the maternal serum concentration of human placental growth hormone (hPGH) in trisomy 21 and trisomy 18 pregnancies at 11 to 13 weeks of gestation and to examine the possible association between fetal nuchal translucency (NT) thickness and maternal serum free beta-human chorionic gonadotrophin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A).
The maternal serum concentration of hPGH at 11 to 13 weeks was measured in a case-control study from 28 pregnancies with fetal trisomy 21, 28 with trisomy 18 and 112 pregnancies with euploid fetuses. The median hPGH multiple of the median (MoM) in trisomy 21 and trisomy 18 pregnancies were compared with euploid pregnancies.
Serum hPGH was significantly lower in trisomy 21 (0.93 MoM) and trisomy 18 (0.62 MoM) compared to euploid pregnancies (1.02 MoM). There was a significant association between serum hPGH and PAPP-A in both the euploid (r = 0.258, p = 0.006) and trisomy 21 pregnancies (r = 0.410, p = 0.030) but not in trisomy 18 pregnancies (p = 0.445).
In the first trimester, serum hPGH in trisomy 21 and trisomy 18 pregnancies is reduced. This is the opposite of findings in previous studies reporting that in the second trimester, trisomy 21 and 18 pregnancies have increased hPGH.
研究 11 至 13 孕周母体血清中人胎盘生长激素（hPGH）在 21 三体和 18 三体妊娠中的浓度，并探讨胎儿颈项透明层（NT）厚度与母体血清游离β-人绒毛膜促性腺激素（β-hCG）和妊娠相关血浆蛋白-A（PAPP-A）之间的可能相关性。
在一项病例对照研究中，对 28 例唐氏综合征胎儿妊娠、28 例 18 三体胎儿妊娠和 112 例正常胎儿妊娠进行了 11 至 13 孕周的母体血清 hPGH 浓度测量。将 21 三体和 18 三体妊娠的 hPGH 中位数倍数（MoM）中位数与正常妊娠进行比较。
21 三体（0.93 MoM）和 18 三体（0.62 MoM）妊娠的血清 hPGH 明显低于正常妊娠（1.02 MoM）。在正常妊娠（r = 0.258，p = 0.006）和 21 三体妊娠（r = 0.410，p = 0.030）中，血清 hPGH 与 PAPP-A 呈显著相关，但在 18 三体妊娠中无相关性（p = 0.445）。
在孕早期，21 三体和 18 三体妊娠的血清 hPGH 降低。这与以前的研究结果相反，以前的研究报告在孕中期，21 三体和 18 三体妊娠的 hPGH 升高。
