利用卵母细胞捐赠模型鉴定早期滋养层的孕烯醇酮生成。
Using the oocyte donation model to identify early trophoblast pregnenolone production.
机构信息
NYU Fertility Center, Division of Reproductive Endocrinology, Department of OBGYN, New York University School of Medicine, New York, NY, USA.
出版信息
J Assist Reprod Genet. 2013 Jun;30(5):699-702. doi: 10.1007/s10815-013-9986-0. Epub 2013 Apr 10.
PURPOSE
To investigate production of progesterone's precursor, pregnenolone, in the early oocyte donation pregnancy.
METHODS
Pregnenolone and progesterone were measured on luteal days 21, 28, 35, 60 and 80. Progesterone was measured via the Immulite system, pregnenolone by liquid chromatography separation with tandem mass spectrometric detection.
RESULTS
Progesterone rose significantly from days 35 today 60. Pregnenolone likewise rose significantly from days 35-60, but at a much higher rate, with an increase of 57% by day 60, 75% to day 80. The increase in pregnenolone was statistically more significant than the increase in progesterone (p < .05).
CONCLUSIONS
This is the first report describing that progesterone's precursor, pregnenolone, increases with time in the very early pregnancy. Because no corpus luteum is present in oocyte recipients, the main source of pregnenolone is the early placenta. Measurements of pregnenolone may provide information concerning early trophoblast function and may represent a method of assessing placental competency.
目的
研究早卵母细胞捐赠妊娠中孕激素前体孕酮醇的产生情况。
方法
在黄体期第 21、28、35、60 和 80 天测量孕酮醇和孕酮。孕酮通过 Immulite 系统测量，孕酮醇通过液相色谱分离与串联质谱检测。
结果
孕酮从第 35 天到第 60 天显著上升。孕酮醇也从第 35 天到第 60 天显著上升，但上升速度更快，第 60 天增加 57%，第 80 天增加 75%。孕酮醇的增加明显高于孕酮（p<0.05）。
结论
这是首次描述孕激素前体孕酮醇在早期妊娠中随时间增加的报告。由于卵母细胞接受者中没有黄体，因此孕酮醇的主要来源是早期胎盘。孕酮醇的测量可能提供有关早期滋养层功能的信息，并可能代表评估胎盘功能的一种方法。
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