Ismail S M
Department of Histopathology, University Hospital of Wales, Cardiff.
Histopathology. 1991 Feb;18(2):107-14. doi: 10.1111/j.1365-2559.1991.tb01452.x.
Cervices from 42 hysterectomies performed from 1 to 91 months (mean 12.2) following conization were re-examined in order to assess the possible effects of post-traumatic regeneration on the endocervix. Twenty-nine (69%) showed a continuum of abnormalities in which the shared finding was the presence of tubo-endometrioid glands, accompanied in many cases by varying amounts of endometrial-type stroma. Thus, 18 post-conization cervices (43%) showed endometriosis, and a further 11 cases (26%) contained tubo-endometrioid glands without demonstrable endometrial-type stroma. These abnormalities were situated at the healed cone biopsy site, either superficially within the new transformation zone and/or within the cone biopsy scar. Post-conization cervical endometriosis occurred from 2 to 91 months (mean 17.8) and tubo-endometrioid metaplasia 2-24 months (mean 11.0) after the cone biopsy. It is concluded that cervical endometriosis and tubo-endometrioid metaplasia are common complications of conization, and that they represent aberrant differentiation following injury. The demonstration of endometriosis and tubo-endometrioid metaplasia in 69% of post-conization cervices has implications for the interpretation of cervical biopsies and smears from this group of women.
为了评估创伤后再生对子宫颈内膜的可能影响，我们重新检查了42例子宫切除术中子宫颈标本，这些子宫切除术是在锥形切除术后1至91个月（平均12.2个月）进行的。29例（69%）显示出一系列异常，共同的发现是存在输卵管子宫内膜样腺体，在许多情况下伴有不同数量的子宫内膜样间质。因此，18例锥形切除术后子宫颈（43%）显示有子宫内膜异位症，另外11例（26%）含有输卵管子宫内膜样腺体，但无明显的子宫内膜样间质。这些异常位于愈合的锥形活检部位，要么在新转化区内表面，和/或在锥形活检瘢痕内。锥形切除术后子宫颈子宫内膜异位症发生在锥形活检后2至91个月（平均17.8个月），输卵管子宫内膜样化生发生在2至24个月（平均11.0个月）。结论是子宫颈子宫内膜异位症和输卵管子宫内膜样化生是锥形切除术的常见并发症，它们代表损伤后的异常分化。在69%的锥形切除术后子宫颈中发现子宫内膜异位症和输卵管子宫内膜样化生，这对解释这组女性的子宫颈活检和涂片有影响。
