McCluggage W G
Department of Pathology, Royal Group of Hospitals Trust, Belfast, UK.
J Clin Pathol. 2003 Mar;56(3):164-73. doi: 10.1136/jcp.56.3.164.
The incidence of malignant and premalignant endocervical glandular lesions is increasing. This review covers controversial and difficult aspects regarding the categorisation and diagnosis of these lesions. The terminology of premalignant endocervical glandular lesions is discussed because of the differences between the UK terminology and the widely used World Health Organisation classification. The morphology and histological subtypes of premalignant endocervical glandular lesions are described. Early invasive adenocarcinoma and difficulties in the diagnosis and recognition of this entity are covered, as is the measurement of early invasion within cervical adenocarcinoma. Several benign endocervical glandular lesions can mimic malignant and premalignant endocervical glandular lesions, and the distinction of these benign mimics from premalignant and malignant lesions using ancillary immunohistochemical studies is also covered. Antibodies used to distinguish between endometrial and endocervical adenocarcinoma, in the diagnosis of cervical minimal deviation adenocarcinoma of mucinous type (adenoma malignum), and in the diagnosis of cervical mesonephric lesions are also reviewed.
子宫颈管内腺性恶性和癌前病变的发病率正在上升。本综述涵盖了这些病变分类和诊断方面存在争议和困难的内容。由于英国术语与广泛使用的世界卫生组织分类之间存在差异，因此对子宫颈管内癌前腺性病变的术语进行了讨论。描述了子宫颈管内癌前腺性病变的形态和组织学亚型。涵盖了早期浸润性腺癌及其诊断和识别的难点，以及子宫颈腺癌早期浸润的测量。几种良性子宫颈管内腺性病变可模仿子宫颈管内恶性和癌前腺性病变，同时还介绍了如何利用辅助免疫组化研究将这些良性模仿病变与癌前和恶性病变区分开来，并对用于鉴别子宫内膜癌和子宫颈管内腺癌、诊断黏液型子宫颈微小偏离腺癌（恶性腺瘤）以及诊断子宫颈中肾病变的抗体进行了综述。
