Blessing K, McLaren K M, McLean A, Davidson P
Department of Pathology, Edinburgh University, Scotland.
Histopathology. 1991 Feb;18(2):143-8. doi: 10.1111/j.1365-2559.1991.tb01456.x.
Thick malignant melanomas in general tend to have a poor prognosis, but exceptions occur where there may be no further recurrence. The reasons for this difference in clinical behaviour are not fully understood. We have looked at thick malignant melanomas (greater than 3.0 mm) in the East of Scotland that have no evidence of metastasis after a minimum of 6 years follow-up and compared the clinical and histological features with a similar group, associated with histological evidence of metastasis and/or death. Both groups received similar treatment regimes. We have identified 41 patients with thick melanomas in the former group. When compared with the control group, factors found to be significantly different between the two groups were: the nature of the lower margin of the tumour; vascular invasion; and anatomical location.
一般来说，厚的恶性黑色素瘤预后往往较差，但也有例外情况，即可能不会再次复发。这种临床行为差异的原因尚未完全明确。我们研究了苏格兰东部厚度超过3.0毫米且经过至少6年随访无转移证据的恶性黑色素瘤，并将其临床和组织学特征与另一组类似患者进行比较，后者有转移和/或死亡的组织学证据。两组接受了相似的治疗方案。我们在前一组中确定了41例厚黑色素瘤患者。与对照组相比，发现两组之间有显著差异的因素包括：肿瘤下缘的性质；血管侵犯；以及解剖位置。
