Blessing K, McLaren K M, McLean A, Davidson P
Department of Pathology, Edinburgh University, UK.
Histopathology. 1990 Nov;17(5):389-95. doi: 10.1111/j.1365-2559.1990.tb00757.x.
It is known that not all thin malignant melanomas have an excellent prognosis and that the specific features identifying the patients at risk of metastasis have not been fully elucidated. We have looked at thin malignant melanomas (less than 1.5 mm) in the East of Scotland that had proven metastasis and death, and compared the clinical and histological features with a similar group (less than 1.5 mm) that have had no further recurrence after a minimum of 6-year follow-up. We identified 26 patients with thin melanomas who had developed histologically proven metastasis and/or died following adequate surgical treatment of their primary lesion. When compared with the control group, factors found to be significantly different between the two groups and present in the group that did badly were (a) histological regression, (b) lesion size, (c) Clark level IV and (d) depth of the uninvolved dermis.
众所周知，并非所有薄型恶性黑色素瘤都有良好的预后，而且确定有转移风险患者的具体特征尚未完全阐明。我们研究了苏格兰东部已证实发生转移和死亡的薄型恶性黑色素瘤（小于1.5毫米），并将其临床和组织学特征与经过至少6年随访且无进一步复发的类似组（小于1.5毫米）进行了比较。我们确定了26例薄型黑色素瘤患者，他们在对其原发性病变进行充分手术治疗后发生了组织学证实的转移和/或死亡。与对照组相比，发现两组之间有显著差异且在预后较差组中存在的因素有：（a）组织学消退，（b）病变大小，（c）克拉克四级，以及（d）未受累真皮的深度。
