Ozerkan K, Ocakoğlu G, Rehimli S, Uncu G, Develioğlu O
Department of Obstetrics and Gynaecology, Uludağ University, Faculty of Medicine, Bursa, Turkey.
Clin Exp Obstet Gynecol. 2009;36(4):245-7.
Sixty patients were randomized to low-dose and high-dose groups, receiving a maximum total dose 1400 g of misoprostol by the vaginal route to compare the efficacy of the protocols for second trimester termination of pregnancy. Outcome measures to be compared between the groups were success rates, time to termination, blood loss, complications and side-effects. Yet time to termination was significantly shorter in the high-dose than in the low-dose group (923 +/- 571 vs 1307 +/- 828 min; p < 0.05). The distance between the internal cervical os and the placenta was positively correlated with the duration of the termination process (r = 0.508, p < 0.001). Induction to the fetal expulsion period is shorter with the higher dose without any significant increase in morbidity. A shorter distance between the internal cervical os and the placenta may forecast a shorter termination process.
60名患者被随机分为低剂量组和高剂量组，通过阴道途径接受最大总剂量1400克米索前列醇，以比较孕中期终止妊娠方案的疗效。两组之间比较的结果指标为成功率、终止时间、失血量、并发症和副作用。然而，高剂量组的终止时间明显短于低剂量组（923±571分钟对1307±828分钟；p<0.05）。宫颈内口与胎盘之间的距离与终止过程的持续时间呈正相关（r=0.508，p<0.001）。高剂量引产至胎儿娩出期的时间较短，且发病率无显著增加。宫颈内口与胎盘之间的距离较短可能预示终止过程较短。
