Cerovski Branimir, Vidović Tomislav, Stiglmayer Neda, Popović Suić Smiljka
Department of Ophthalmology, University Hospital Center Zagreb, Zagreb, Croatia.
Coll Antropol. 2009 Dec;33(4):1421-2.
Optic nerve can be infiltrated with various tumors and inflammatory processes, with a considerable prevalence of primary over secondary tumors. Metastases of gastric carcinoma to the optic nerve are less frequently, and those of prostatic carcinoma very infrequently observed. A 66-year-old man presented with metastasis to the optic nerve with consequential vision loss to the level of light perception developed two years after prostatic surgery. Systemic therapy with methylprednisolone resulted in a satisfactory vision function recovery. According to literature data, prostatic carcinoma metastases to the optic nerve occur very rarely. In our patient with the optic nerve infiltration found on the first clinical examination, papillary edema was associated with the signs of optic nerve functional impairment (visual acuity, visual field, unilateral RAPD). An infiltrative process involving a distal portion of the optic nerve usually does not cause papillary alterations, and produces a clinical picture of retrobulbar optic neuropathy, such as that observed in our patient on the second clinical examination, showing the signs of optic nerve damage.
视神经可被各种肿瘤和炎症侵犯,原发性肿瘤的发生率远高于继发性肿瘤。胃癌转移至视神经较少见,前列腺癌转移至视神经则极为罕见。一名66岁男性在前列腺手术后两年出现视神经转移,导致视力丧失至仅存光感。甲泼尼龙全身治疗使视力功能恢复良好。根据文献资料,前列腺癌转移至视神经极为罕见。在我们的患者中,首次临床检查发现视神经浸润,视乳头水肿与视神经功能损害(视力、视野、单侧相对性传入性瞳孔障碍)体征相关。累及视神经远端的浸润性病变通常不会引起视乳头改变,而是产生球后视神经病变的临床表现,如我们的患者在第二次临床检查时所见,显示出视神经损害的体征。