Atlantic Food and Horticulture Research Centre, Agriculture and Agri-Food Canada, Kentville, Nova Scotia, Canada.
J Agric Food Chem. 2010 Apr 14;58(7):4001-7. doi: 10.1021/jf903038r.
A long-standing yet controversial bioactivity attributed to polyphenols is their beneficial effects in vision. Although anecdotal case reports and in vitro research studies provide evidence for the visual benefits of anthocyanin-rich berries, rigorous clinical evidence of their benefits is still lacking. Recent in vitro studies demonstrate that anthocyanins and other flavonoids interact directly with rhodopsin and modulate visual pigment function. Additional in vitro studies show flavonoids protect a variety of retinal cell types from oxidative stress-induced cell death, a neuroprotective property of significance because the retina has the highest metabolic rate of any tissue and is particularly vulnerable to oxidative injury. However, more information is needed on the bioactivity of in vivo conjugates and the accumulation of flavonoids in ocular tissues. The direct and indirect costs of age-related vision impairment provide a powerful incentive to explore the potential for improved vision health through the intake of dietary polyphenolics.
多酚具有改善视力的作用，这是一个由来已久但仍具争议的生物学活性。尽管轶事病例报告和体外研究为富含花青素的浆果对视力的益处提供了证据，但仍缺乏其益处的严格临床证据。最近的体外研究表明，花青素和其他类黄酮可直接与视紫红质相互作用，并调节视觉色素功能。此外，体外研究表明类黄酮可保护多种视网膜细胞免受氧化应激诱导的细胞死亡，这是一种神经保护特性，因为视网膜的代谢率是所有组织中最高的，特别容易受到氧化损伤。然而，人们需要更多关于体内结合物的生物活性和类黄酮在眼部组织中的积累的信息。与年龄相关的视力障碍的直接和间接成本为通过摄入饮食多酚来改善视力健康提供了强大的动力。
